| Date | Location | Result | |
| Nov 18, 2010 | Warrensburg, Mo. | Central Missouri 3, St. Mary's (Texas) 0 (25-19,25-17,25-10) | Box score |
| Nov 13, 2010 | Austin, Texas | St. Mary's (Texas) 3, Dallas Baptist 1 (26-24,18-25,25-21,25-16) | Box score |
| Nov 12, 2010 | Austin, Texas | St. Mary's (Texas) 3, Newman 0 (25-19,25-18,25-22) | Box score |
| Nov 06, 2010 | Dallas, TX | St. Mary's (Texas) 3, Dallas Baptist 2 (25-22,25-21,22-25,23-25,15-11) | Box score |
| Nov 04, 2010 | Austin, Texas | St. Edward's 3, St. Mary's (Texas) 1 (25-13,20-25,26-24,25-17) | Box score |
| Oct 30, 2010 | San Antonio, Texas | West Texas A&M 3, St. Mary's (Texas) 0 (25-14,25-19,25-22) | Box score |
| Oct 29, 2010 | San Antonio, TX | Angelo State 3, St. Mary's (Texas) 1 (17-25,25-19,25-17,25-14) | Box score |
| Oct 27, 2010 | Laredo, Texas | St. Mary's (Texas) 3, A&M International 0 (25-18,25-22,25-15) | Box score |
| Oct 23, 2010 | Fort Smith, Ark. | Arkansas-Fort Smith 3, St. Mary's (Texas) 0 (25-16,25-21,25-20) | Box score |
| Oct 21, 2010 | Wichita, Kan. | St. Mary's (Texas) 3, Newman 2 (21-25,25-18,25-19,23-25,15-11) | Box score |
| Oct 16, 2010 | San Antonio, TX | St. Mary's (Texas) 3, Southern Arkansas 2 (27-25,24-26,25-27,25-19,15-9) | Box score |
| Oct 16, 2010 | San Antonio, TX | St. Mary's (Texas) 3, OPSU 0 (25-17,25-19,25-14) | Box score |
| Oct 14, 2010 | San Antonio, TX | St. Mary's (Texas) 3, Texas-Permian Basin 2 (24-26,25-20,25-19,17-25,15-11) | Box score |
| Oct 12, 2010 | San Antonio, TX | St. Mary's (Texas) 3, Incarnate Word 1 (26-24,25-23,18-25,25-22) | Box score |
| Oct 09, 2010 | St. Mary's Univ. | Dallas Baptist 3, St. Mary's (Texas) 2 (25-21,18-25,26-24,24-26,15-6) | Box score |
| Oct 07, 2010 | San Antonio, TX | St. Edward's 3, St. Mary's (Texas) 2 (23-25,22-25,25-21,25-19,15-5) | Box score |
| Oct 02, 2010 | Durant, OK | Midwestern State 3, St. Mary's (Texas) 0 (25-20,25-22,25-23) | Box score |
| Oct 02, 2010 | Durant, OK | Oklahoma Baptist 3, St. Mary's (Texas) 0 (25-22,25-20,25-21) | Box score |
| Oct 01, 2010 | Durant, OK | Southeastern Okla. 3, St. Mary's (Texas) 0 (25-20,25-16,25-19) | Box score |
| Sep 29, 2010 | San Antonio, TX | St. Mary's (Texas) 3, A&M International 0 (25-16,25-16,25-13) | Box score |
| Sep 25, 2010 | Goodwell, Ok | Panhandle State Univ 3, St. Mary's (Texas) 2 (23-25,15-25,25-23,25-23,15-12) | Box score |
| Sep 23, 2010 | Odessa, Texas | St. Mary's (Texas) 3, Texas-Permian Basin 1 (25-23,19-25,25-19,27-25) | Box score |
| Sep 18, 2010 | San Antonio, TX | St. Mary's (Texas) 3, Arkansas-Fort Smith 1 (25-19,20-25,25-11,27-25) | Box score |
| Sep 16, 2010 | San Antonio, TX | Newman 3, St. Mary's (Texas) 1 (19-25,25-21,25-14,25-22) | Box score |
| Sep 11, 2010 | Stephenville, TX | Midwestern State 3, St. Mary's (Texas) 2 (16-25,23-25,25-10,25-18,15-6) | Box score |
| Sep 11, 2010 | Stephenville, TX | St. Mary's (Texas) 3, Cameron 1 (20-25,25-20,25-15,25-19) | Box score |
| Sep 10, 2010 | Stephenville, TX | Texas A&M-Commerce 3, St. Mary's (Texas) 0 (25-19,25-15,28-26) | Box score |
| Sep 10, 2010 | Stephenville, TX | Tarleton 3, St. Mary's (Texas) 2 (22-25,28-26,25-20,21-25,15-7) | Box score |
| Sep 07, 2010 | San Antonio, TX | Incarnate Word 3, St. Mary's (Texas) 0 (25-21,25-23,25-22) | Box score |
| Sep 04, 2010 | San Antonio, TX | St. Mary's (Texas) 3, Maryville 0 (25-15,25-13,25-15) | Box score |
| Sep 03, 2010 | San Antonio, TX | Washburn 3, St. Mary's (Texas) 0 (25-19,25-12,25-11) | Box score |
| Sep 03, 2010 | San Antonio, TX | Wheeling Jesuit 3, St. Mary's (Texas) 0 (25-16,25-17,25-16) | Box score |
| Sep 02, 2010 | San Antonio, TX | St. Mary's (Texas) 3, SW Oklahoma St. 0 (25-15,25-20,25-14) | Box score |